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Peptide record

TPDB64312

NPFSD Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB64312
NPFSD
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Extended with G4S Peptide Linker
Sequence
VLTNENPFSDP
Physicochemical Analysis
C54H81N13O20
ARCQGHIKMWY
NP
1232.31
3.01
0
2
3
-2
3.64
-0.718
61.82
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
0
A
0
R
2
N
1
D
0
C
1
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
2
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 1 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
11
C54H81N13O20
1232.31
3.01
-2
3.64
-0.718
Extended with G4S Peptide Linker
L
Linear
Free
N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

C. Albicans Strain Sc5314

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
GFP via linker
Cytoplasm
Translocation of NPFSD-GFP led to 1.2 times as many GFP-positive cells compared to GFP only, and with G4S linker 58 % more GFP-positive cells compared to the construct lacking the linker
In vitro
CTTCSSCCCCC
Additional Detail Fields 1 fields
CTTCSSCCCCC