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Peptide record

TPDB64311

Stereo-chemical Amphipathic chaRged Tumor Homing and Internalizing(SARTHI)-2 Stereo-chemical Amphipathic chaRged Tumor Homing and Internalizing(SARTHI)-4 SARTH2 SARTH4 Cell-penetrating Peptides Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64311
Stereo-chemical Amphipathic chaRged Tumor Homing and Internalizing(SARTHI)-2 Stereo-chemical Amphipathic chaRged Tumor Homing and Internalizing(SARTHI)-4 SARTH2 SARTH4
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 TumorHoPe2.0
standard
No
A 12-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0 and TumorHoPe2.0, with an available 3D structural model.
Sequence
VLIKCRLFIKRK
Physicochemical Analysis
C71H129N21O13S1
ANDEQGHMPSTWY
K
1517.00
11.56
5
0
6
+5
1.55
0.450
154.17
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
2
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
2
I
2
L
3
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 2 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
12
C71H129N21O13S1
1517.00
11.56
+5
1.55
0.450
Free
L
Amphipathic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, MDA-MB-231 And Hek-293 Cells U-87 Mg Glioblastoma Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
5(6)-carboxyfluorescein (CF) and MTX
Vesicles
Concentration-dependent internalization
Energy independent pathways
In vitro
CCCCCCSSTTCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, MDA-MB-231 And Hek-293 Cells U-87 Mg Glioblastoma Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Synthetic
5(6)-carboxyfluorescein (CF) and MTX
Vesicles
Concentration-dependent internalization
Energy-dependent and energy-independent pathways
In vitro
CCCCCCSSTTCC
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Homing
Breast cancer, Cervical cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Syndiotactic peptides for targeted delivery
2019
Jerath G et al. Acta Biomater. 2019 Mar 15:87:130-139.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
MDA-MB-231, HEK-293, HeLa, U87-MG
Synthetic
methotrexate(MTX), 5(6)-carboxyfluorescein
LDLD configuration, cell penetrating peptide
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Homing
Breast cancer, Cervical cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Syndiotactic peptides for targeted delivery
2019
Jerath G et al. Acta Biomater. 2019 Mar 15:87:130-139.

Other

MDA-MB-231, HEK-293, HeLa, U87-MG
Synthetic
methotrexate(MTX), 5(6)-carboxyfluorescein
DLDL configuration, cell penetrating peptide
Additional Detail Fields 3 fields
methotrexate(MTX), 5(6)-carboxyfluorescein
CCCCCCSSTTCC
MDA-MB-231, HEK-293, HeLa, U87-MG