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Peptide record

TPDB64301

Mut4DPT Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64301
Mut4DPT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with FITC
Sequence
VKKWKIKWWIKI
Physicochemical Analysis
C86H134N20O13
ARNDCEQGHLMFPSTY
K
1656.14
11.12
5
0
7
+5
-1.46
-0.375
121.67
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
16500
996.29
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
0
L
5
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 0 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
12
C86H134N20O13
1656.14
11.12
+5
-1.46
-0.375
Conjugated with FITC
L
Linear
Free
N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF7, Jurkat Cells, MDA-MB232

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FITC dye and PP2A/SET peptide
Cytoplasm and nucleus
Rapid internalization and stronger than in the control Mut3DPT shuttle
In vitro
CCSSGGGGTTTTC
Additional Detail Fields 1 fields
CCSSGGGGTTTTC