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Peptide record

TPDB64294

Mut3DPT-C9h Cell-penetrating Peptides standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB64294
Mut3DPT-C9h
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 30-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Mutation at position 8 and Cy5 labelled
Sequence
VKKKKIKAEIKIYVETLDDIFEQWAHSEDL
Physicochemical Analysis
C167H266N40O49
RNCGMP
K
3618.19
5.54
7
7
13
-1
13.04
-0.597
104.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
6990
193.19
4
Residue Composition
number
2
A
0
R
0
N
3
D
0
C
4
E
1
Q
0
G
1
H
4
I
2
L
6
K
0
M
1
F
0
P
1
S
1
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 3 C: 0 E: 4 Q: 1 G: 0 H: 1 I: 4 L: 2 K: 6 M: 0 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 1 V: 2
Chemical Descriptors
30
C167H266N40O49
3618.19
5.54
-1
13.04
-0.597
Free
Mutation at position 8 and Cy5 labelled
L
Cationic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hbcx-3, Hbcx-12A, Hbcx-17

Assay & Model

Breast cancer xenograft model (Nude Mice)
Breast cancer xenograft model (Nude Mice)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Cy5-labeled
Mut3DPT-C9h peptide showed the highest intensity of fluorescence between 23 and 73 h
In vitro and in vivo
CCCTTSCC
Additional Detail Fields 1 fields
CCCTTSCC