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Peptide record

TPDB64291

PolyP 6 Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB64291
PolyP 6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Conjugation with fluorescein
Sequence
VHLPPPVHLPPPVHLPPP
Physicochemical Analysis
C96H146N24O19
ARNDCEQGIKMFSTWY
P
1940.36
8.09
3
0
6
+0
5.46
-0.000
113.33
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
3
H
0
I
3
L
0
K
0
M
0
F
9
P
0
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 3 I: 0 L: 3 K: 0 M: 0 F: 0 P: 9 S: 0 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
18
C96H146N24O19
1940.36
8.09
+0
5.46
-0.000
Free
L
Amphipathic
Linear
Conjugation with fluorescein
N[C@@H](C(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
Fluorophore (fluorescein)
Punctate cytoplasmic distribution (vesicles)
Low
Probably endocytic pathway
In vitro
CCCCSCSCTTCCCCC
Additional Detail Fields 1 fields
CCCCSCSCTTCCCCC