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Peptide record

TPDB64277

Phage clone 1.2 Phage clone 1.3 Blood-Brain Barrier Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64277
Phage clone 1.2 Phage clone 1.3
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0
standard
No
A 12-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
Sequence
VAARTGEIYVPW
Physicochemical Analysis
C64H96N16O17
NDCQHLKMFS
AV
1361.56
6.90
1
1
7
-0
0.13
0.300
97.50
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
6990
513.38
2
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
0
S
1
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 1 W: 1 Y: 1 V: 2
Chemical Descriptors
12
C64H96N16O17
1361.56
6.90
-0
0.13
0.300
Free
L
Linear
Linear
Free
Similarity
Cationic
ValAlaAlaArgThrGlyGluIleTyrValProTrp
N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=CN2)C1=C2C=CC=C1)C(=O)O NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
1.5 x 10e-6 cm/s

Target

SH-SY5Y cells

Assay & Model

UHPLC-MS/MS
The phage display adverses the BBB with the peptide.
Origin/Source
Stability/half life

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Peptides bound specifically to primary endothelial cells and could traverse the BBB.
Transcytosis
Combined with phage display
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Primary Rat Endothelial Cells And SH-SY5Y Neuroblastoma Cell Line.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Biotin-labeled
Able to internalize into primary endothelial cells (with higher efficiency than GLHTSATNLYLH) while internalization of N–C reversed sequence peptide into primary endothelial cells was negligible.
Energy dependent pathway
In vitro
CCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCC