Back to search

Peptide record

TPDB64268

FLH Cell-penetrating Peptides standard
41 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB64268
FLH
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 41-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: GET Nanoparticle
Sequence
TYRSRKYTSWYVALKRKLLKLLLKLLLKLLKHHHHHHHHHH
Physicochemical Analysis
C246H388N78O49
NDCEQGIMFP
L
5222.28
11.27
20
0
17
+11
8.57
-0.800
114.15
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
9970
190.91
7
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
10
H
0
I
11
L
7
K
0
M
0
F
0
P
2
S
2
T
1
W
3
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 10 I: 0 L: 11 K: 7 M: 0 F: 0 P: 0 S: 2 T: 2 W: 1 Y: 3 V: 1
Chemical Descriptors
41
C246H388N78O49
5222.28
11.27
+11
8.57
-0.800
Free
GET Nanoparticle
L
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=NC=NC1)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Nih3T3 Fibroblast Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Gaussia luciferase reporter pDNA
FLR:FLH formulations generated significantly higher transfection levels at the lowest dosages.
In vitro
CCSSCSSSSSCSCCCTTSTTCCSCCBTTBC
Additional Detail Fields 1 fields
CCSSCSSSSSCSCCCTTSTTCCSCCBTTBC