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Peptide record

TPDB64244

T3BP Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB64244
T3BP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 28-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
TRRRRAKRSPKHHSQRARKKNKNCRRHS
Physicochemical Analysis
C142H255N69O36S1
DEGILMFWYV
R
3537.09
12.95
17
0
2
+14
16.94
-2.811
7.14
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
8
Residue Composition
number
2
A
9
R
2
N
0
D
1
C
0
E
1
Q
0
G
3
H
0
I
0
L
5
K
0
M
0
F
1
P
3
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 9 N: 2 D: 0 C: 1 E: 0 Q: 1 G: 0 H: 3 I: 0 L: 0 K: 5 M: 0 F: 0 P: 1 S: 3 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
28
C142H255N69O36S1
3537.09
12.95
+14
16.94
-2.811
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549, HeLa,Smmc-7721 And Mgc803 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
EGFP and TriCHOsanthin (TCS)
Endoplasmic Reticulum and Golgi Complex
The green fluorescence intensity of EGFP-T3BPd was higher in A549 cells and HeLa cells, but lower in SMMC-7721 and MGC803 cells and was about twice that of EGFP-TAT in HeLa cells.
Clathrin mediated endocytosis
In vitro
CCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCC