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Peptide record

TPDB64238

Rev-R11W/W12R/R15Q/Q16R Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB64238
Rev-R11W/W12R/R15Q/Q16R
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-TRQARRNRRRWRREQRR-NH2
Physicochemical Analysis
C97H173N51O24
DCGHILKMFPSYV
R
2437.77
13.00
10
1
2
+9
9.82
-3.459
5.88
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
5500
225.62
4
Residue Composition
number
1
A
10
R
1
N
0
D
0
C
1
E
2
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 10 N: 1 D: 0 C: 0 E: 1 Q: 2 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
17
C97H173N51O24
2437.77
13.00
+9
9.82
-3.459
Amidation
L
Cationic
Linear
Acetylation
N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
FAM via glycylglycine linker at N terminus
Rev-R11W/W12R/R15Q/Q16R exhibits the cell penetration efficiency comparable to Rev
In vitro
CCCBTTBCSCHHHHCCC
Additional Detail Fields 1 fields
CCCBTTBCSCHHHHCCC