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Peptide record

TPDB64237

HIV-1 Rev (34-50) Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB64237
HIV-1 Rev (34-50)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Conjugation with Alexa 488 at glycyl cysteine sequence
Sequence
TRQARRNRRRRWRERQRGC
Physicochemical Analysis
C102H181N53O26S1
DHILKMFPSYV
R
2597.96
12.77
10
1
2
+9
9.59
-2.984
5.26
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
5500
211.70
5
Residue Composition
number
1
A
10
R
1
N
0
D
1
C
1
E
2
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 10 N: 1 D: 0 C: 1 E: 1 Q: 2 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
19
C102H181N53O26S1
2597.96
12.77
+9
9.59
-2.984
Conjugation with Alexa 488 at glycyl cysteine sequence
L
Cationic
Linear
Free
N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1, HeLa and Jurkat

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (Alexa-488)
2.5–6.6 times more than the Tat (48–60) peptid
In vitro
CCSCTHHHHHHHHHHHTTC
Additional Detail Fields 1 fields
CCSCTHHHHHHHHHHHTTC