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Peptide record

TPDB64225

TPLFT Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64225
TPLFT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
TPLFTQEATGAN
Physicochemical Analysis
C54H84N14O20
RDCHIKMSWYV
T
1249.34
3.29
0
1
4
-1
1.87
-0.367
49.17
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
1
E
1
Q
1
G
0
H
0
I
1
L
0
K
0
M
1
F
1
P
0
S
3
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 3 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C54H84N14O20
1249.34
3.29
-1
1.87
-0.367
Free
L
Linear
Free
N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mc3T3-E1 Cell Line, Caco-2 Cells,

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
eGFP at C terminus
Moderate uptake compared to the unmodified negative control eGFP in MC3TS-E1 cells but no uptake in Caco-2 cells
In vitro
CCSSCTTSCCC
Additional Detail Fields 1 fields
CCSSCTTSCCC