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Peptide record

TPDB64208

Kev Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB64208
Kev
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-TKQAKKNKKKKWKEKQK-NH2
Physicochemical Analysis
C97H173N31O24
RDCGHILMFPSYV
K
2157.63
11.11
10
1
2
+9
11.62
-3.106
5.88
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
5500
254.91
4
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
1
E
2
Q
0
G
0
H
0
I
0
L
10
K
0
M
0
F
0
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 2 G: 0 H: 0 I: 0 L: 0 K: 10 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
17
C97H173N31O24
2157.63
11.11
+9
11.62
-3.106
Amidation
L
Cationic
Linear
Acetylation
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
FAM via glycylglycine linker at N terminus
No cell penetration was observed for the corresponding lysine peptides (FAM-K8 and FAM-Kev)
In vitro
CCSTTCCC
Additional Detail Fields 1 fields
CCSTTCCC