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Peptide record

TPDB64200

M1-RGD Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB64200
M1-RGD
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
TFYGGRPKRNNFLRGIRSRGD
Physicochemical Analysis
C107H171N39O29
ACEQHMWV
R
2467.78
12.23
6
1
5
+5
3.80
-1.381
37.14
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1490
60.38
5
Residue Composition
number
0
A
5
R
2
N
1
D
0
C
0
E
0
Q
4
G
0
H
1
I
1
L
1
K
0
M
2
F
1
P
1
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 2 D: 1 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 1 L: 1 K: 1 M: 0 F: 2 P: 1 S: 1 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
21
C107H171N39O29
2467.78
12.23
+5
3.80
-1.381
Free
L
Linear
Free
N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87Mg Cells

Assay & Model

U87MG-Luc bearing BALB/c Nude mice model
U87MG-Luc bearing BALB/c Nude mice model

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Cy5.5 Labelling and PTXpaclitaxel (PTX) at N -terminus
Both the M1 and M1-RGD peptides were efficiently taken up by U87MG cells. Quantitative analysis indicated that M1-RGD exhibited a better tumor targeting efficacy than M1. M1-RGD-PTX exhibited higher cellular uptake which was consistent with its higher cytotoxicity
In vitro and in vivo
CCSTTTTTCCCSSSSCC
Additional Detail Fields 1 fields
CCSTTTTTCCCSSSSCC