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Peptide record

TPDB64199

M1 Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB64199
M1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
TFYGGRPKRNNFLRGIR
Physicochemical Analysis
C92H146N32O22
ADCEQHMSWV
R
2052.37
12.41
5
0
5
+5
1.62
-1.165
45.88
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1490
72.60
4
Residue Composition
number
0
A
4
R
2
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
1
L
1
K
0
M
2
F
1
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 1 K: 1 M: 0 F: 2 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
17
C92H146N32O22
2052.37
12.41
+5
1.62
-1.165
Free
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87Mg Cells

Assay & Model

U87MG-Luc bearing BALB/c Nude mice model
U87MG-Luc bearing BALB/c Nude mice model

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Cy5.5 Labelling and PTXpaclitaxel (PTX) at N -terminus
Both the M1 and M1-RGD peptides were efficiently taken up by U87MG cells
In vitro and in vivo
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC