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Peptide record

TPDB64196

Angiopep-2 Cell-penetrating Peptides Tumor-homing Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB64196
Angiopep-2
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 TumorHoPe2.0
standard
No
A 20-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0 and TumorHoPe2.0, with an available 3D structural model.
Sequence
TFFYGGSRGKRNNFKTEEYC
Physicochemical Analysis
C107H154N30O32S1
ADQHILMPWV
GF
2404.64
9.53
4
2
5
+2
3.41
-1.295
0.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
2980
123.93
8
Residue Composition
number
0
A
2
R
2
N
0
D
1
C
2
E
0
Q
3
G
0
H
0
I
0
L
2
K
0
M
3
F
0
P
1
S
2
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 2 D: 0 C: 1 E: 2 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 2 M: 0 F: 3 P: 0 S: 1 T: 2 W: 0 Y: 2 V: 0
Chemical Descriptors
20
C107H154N30O32S1
2404.64
9.53
+2
3.41
-1.295
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Targeting
Brain tumor
LRP Receptor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-targeting dual peptides-modified cationic liposomes for delivery of siRNA and docetaxel to gliomas
2014
Yang Z Z et al. Biomaterials.2014 Jun 35(19):5226-39

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
U251 MG cells (human glioblastoma cells), C6 cells (rat glioma cells), U87 MG cells (human glioblastoma cells), BMVEC (murine brain microvascular endothelial cells)
Male BALB/c nude mice
Synthetic
Polyethylene glycol (PEG)
Additional Detail Fields 3 fields
Polyethylene glycol (PEG)
U251 MG cells (human glioblastoma cells), C6 cells (rat glioma cells), U87 MG cells (human glioblastoma cells), BMVEC (murine brain microvascular endothelial cells)
Male BALB/c nude mice