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Peptide record

TPDB64177

PHI 21 N (12-29) Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB64177
PHI 21 N (12-29)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Conjugation with fluorescein by C-terminal Gly Cys amide
Sequence
TAKTRYKARRAELIAERRGC
Physicochemical Analysis
C98H173N37O28S1
NDQHMFPSWV
R
2349.74
11.29
7
2
7
+5
7.63
-1.120
59.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1490
63.41
4
Residue Composition
number
4
A
5
R
0
N
0
D
1
C
2
E
0
Q
1
G
0
H
1
I
1
L
2
K
0
M
0
F
0
P
0
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 5 N: 0 D: 0 C: 1 E: 2 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 2 M: 0 F: 0 P: 0 S: 0 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
20
C98H173N37O28S1
2349.74
11.29
+5
7.63
-1.120
Conjugation with fluorescein by C-terminal Gly Cys amide
L
Cationic
Linear
Free
N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

RAW 264.7

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (fluorescein)
Cytoplasm and nucleus
Less relative to Tat-(48–60) peptide
Non-endocytic mechanism
In vitro
CCTTTCBTTBTTHHHHHHHC
Additional Detail Fields 1 fields
CCTTTCBTTBTTHHHHHHHC