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Peptide record

TPDB64163

RAN Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64163
RAN
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with Cyanine5.5-N-Hydroxysuccinimide (Cy5.5)
Sequence
STLMKFCYVEQN
Physicochemical Analysis
C64H99N15O20S2
ARDGHIPW
NCEQLKMFSTYV
1462.70
6.28
1
1
5
-0
1.25
-0.167
56.67
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1490
101.87
6
Residue Composition
number
0
A
0
R
1
N
0
D
1
C
1
E
1
Q
0
G
0
H
0
I
1
L
1
K
1
M
1
F
0
P
1
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 1 E: 1 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 1 M: 1 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
12
C64H99N15O20S2
1462.70
6.28
-0
1.25
-0.167
Free
L
Linear
Conjugated with Cyanine5.5-N-Hydroxysuccinimide (Cy5.5)
N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

H9C2 Cells , Ipsc Cell Lines,

Assay & Model

6-8 week-old wild-type CD1 mice
6-8 week-old wild-type CD1 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Cyanine5.5 (Cy5.5) dye
No fluorescence noted in the RAN-Cy5.5 injected mouse hearts
In vitro and in vivo
CCTTSCCCCCCC
Additional Detail Fields 1 fields
CCTTSCCCCCCC