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Peptide record

TPDB64147

NNJA_15 Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB64147
NNJA_15
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
SSRPPIVTP
Physicochemical Analysis
C42H72N12O13
ANDCEQGHLKMFWY
P
953.11
11.05
1
0
2
+1
2.32
-0.322
75.56
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
3
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 3 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
9
C42H72N12O13
953.11
11.05
+1
2.32
-0.322
Free
L
Hydrophobic
Linear
Free
N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek-239 ,Caco2 Cells, SH-SY5Y Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Phage Display
IgG4 antibody
Cytosol
Substantial levels of antibodies internalization in cells apart from CPP-12-AF488 peptide (no cargo attached) which showed no uptake after 3 hr and 24 hr incubation.
In vitro
CCSCCCCCC
Additional Detail Fields 1 fields
CCSCCCCCC