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Peptide record

TPDB64146

KRP Cell-penetrating Peptides standard
54 amino acids
Basic Information
3D PDB MODEL
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TPDB64146
KRP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 54-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
SSKEKKKGKKRKKKREREGQKEGGRRKEKRKEKKRKEGGREGRKEGRKSADHPS
Physicochemical Analysis
C264H477N105O80
NCILMFTWYV
K
6402.35
11.42
29
10
1
+18
47.75
-3.020
1.85
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
1
A
10
R
0
N
1
D
0
C
9
E
1
Q
8
G
1
H
0
I
0
L
18
K
0
M
0
F
1
P
4
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 10 N: 0 D: 1 C: 0 E: 9 Q: 1 G: 8 H: 1 I: 0 L: 0 K: 18 M: 0 F: 0 P: 1 S: 4 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
54
C264H477N105O80
6402.35
11.42
+18
47.75
-3.020
Free
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MG63 and HUVECs

Assay & Model

5-week old male BALB / c node mice
5-week old male BALB / c node mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Synthetic
FITC dye and Doxorubicin (DOX)
Cytosol, nuclei and lysosomes
Dose and concentration-dependent internalization
Endocytosis
In vitro and ex vivo