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Peptide record

TPDB64129

DPV10/6 Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB64129
DPV10/6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Cys addition
Sequence
SRRARRSPRESGKKRKRKR
Physicochemical Analysis
C96H183N47O25
NDCQHILMFTWYV
R
2395.81
12.88
12
1
1
+11
13.14
-3.037
5.26
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
8
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
0
I
0
L
4
K
0
M
0
F
1
P
3
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 8 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
19
C96H183N47O25
2395.81
12.88
+11
13.14
-3.037
Free
L
Linear
Cys addition
N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, HCT116, HL-60, K562, Molt4, NIH-3T3 and primary hepatocyte cultures

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Protein (PO and IgG)
Cytoplasm
Energy-dependent endocytic process involving cell membrane lipid rafts
In vitro
CCCBCSSCBSBSSSCBCCC
Additional Detail Fields 1 fields
CCCBCSSCBSBSSSCBCCC