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Peptide record

TPDB64124

TcdB2(termed PepB2) Cell-penetrating Peptides standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB64124
TcdB2(termed PepB2)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 40-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
SQVKIRFTNVFKGNTISDKISFNFSDKQDVSINKVISTFT
Physicochemical Analysis
C205H326N54O63
ACEHLMPWY
S
4555.17
10.38
6
3
14
+3
6.72
-0.255
77.75
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
16
Residue Composition
number
0
A
1
R
4
N
3
D
0
C
0
E
2
Q
1
G
0
H
5
I
0
L
5
K
0
M
5
F
0
P
6
S
4
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 0 R: 1 N: 4 D: 3 C: 0 E: 0 Q: 2 G: 1 H: 0 I: 5 L: 0 K: 5 M: 0 F: 5 P: 0 S: 6 T: 4 W: 0 Y: 0 V: 4
Chemical Descriptors
40
C205H326N54O63
4555.17
10.38
+3
6.72
-0.255
Free
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Nih/3T3, CHO-K1, Or HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
TfAF488 or 0.2-μm microspheres , lentivirus particles carrying the pac gene
Lysosomes
PepB2 show greater efficacy than other
Cell-surface binding and macropinocytosis
In vitro
CCSSSCCSBTTTSBSSCC
Additional Detail Fields 1 fields
CCSSSCCSBTTTSBSSCC