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Peptide record

TPDB64120

H5-pHACS Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64120
H5-pHACS
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
SPQRESRRKKKR
Physicochemical Analysis
C63H118N28O18
ANDCGHILMFTWYV
R
1555.81
12.42
7
1
0
+6
9.52
-3.325
0.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
1
E
1
Q
0
G
0
H
0
I
0
L
3
K
0
M
0
F
1
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C63H118N28O18
1555.81
12.42
+6
9.52
-3.325
Free
L
Linear
Free
N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Dc2.4 Cells, A549 Cells CHO-K1 Cells, And Mutant CHO Cells

Assay & Model

Male, 6-week-old C57BL/6 J mice
Male, 6-week-old C57BL/6 J mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
NeutrAvidin
H5-pHACS and H7-pHACS, can bind and internalized into several cell types while others not
In vitro and in vivo
CTTSSSSCCTTC
Additional Detail Fields 1 fields
CTTSSSSCCTTC