Back to search

Peptide record

TPDB64110

SP90-C Cell-penetrating Peptides standard
39 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB64110
SP90-C
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 39-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
SMDPFLFQLLQLGPGLWERQAREHSERKKRRRESECKAA
Physicochemical Analysis
C203H328N66O58S2
NITYV
R
4685.36
10.30
10
6
12
+3
15.28
-1.187
57.69
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5500
117.39
7
Residue Composition
number
3
A
6
R
0
N
1
D
1
C
5
E
3
Q
2
G
1
H
0
I
5
L
3
K
1
M
2
F
2
P
3
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 6 N: 0 D: 1 C: 1 E: 5 Q: 3 G: 2 H: 1 I: 0 L: 5 K: 3 M: 1 F: 2 P: 2 S: 3 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
39
C203H328N66O58S2
4685.36
10.30
+3
15.28
-1.187
Free
L
Linear
Free
NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 Cell Cancer Cell Lines (HeLa, Hep G2, A549, MCF-7) And Normal Breast Cells (Nhfb).

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
EGFP and VPR proteins
Cytoplasm
SP90-C increased the intracellular delivery efficiency by 12-fold or 10-fold compared to SP90 or C peptide alone, respectively.
Receptor mediated endocytosis
In vitro
CCCSTHHHHSSSTTTTTCCTTSSSCC
Additional Detail Fields 1 fields
CCCSTHHHHSSSTTTTTCCTTSSSCC