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Peptide record

TPDB64109

SP90 Cell-penetrating Peptides Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64109
SP90
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 TumorHoPe2.0
standard
No
A 12-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0 and TumorHoPe2.0, with an available 3D structural model.
Sequence
SMDPFLFQLLQL
Physicochemical Analysis
C69H106N14O18S1
ARNCEGHIKTWYV
L
1451.74
3.10
0
1
7
-1
-1.76
0.817
130.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
2
Q
0
G
0
H
0
I
4
L
0
K
1
M
2
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 4 K: 0 M: 1 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C69H106N14O18S1
1451.74
3.10
-1
-1.76
0.817
Free
L
Linear
Free
N[C@@H](Cc1[nH]cnc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 Cell Cancer Cell Lines (HeLa, Hep G2, A549, MCF-7) And Normal Breast Cells (Nhfb).

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
EGFP and VPR proteins
Cytoplasm
The C peptide increased the EGFP uptake in all tested cells, while SP90 and SP90-C only improved the uptake of EGFP in breast cancer cells.
Receptor mediated endocytosis
In vitro
CGGGTGGGTSSTTGGGTCC
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Improved breast cancer cell-specific intracellular drug delivery and therapeutic efficacy by coupling decoration with cell penetrating peptide and SP90 peptide
2016
Li-Qiang Fan et al. Biomed Pharmacother. 2016 Dec:84:1783-1791.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
MDA-MB-231 breast cancer cells, MCF-7 cells, NHFB normal breast cells, A549 lung cancer cells, HeLa cervical cancer cells, HepG2 hepatoma cells
Phage display library
HIV-1 Viral Protein R (Vpr), Enhanced Green Fluorescent Protein (EGFP), Cell-penetrating peptide (C peptide: GPGLWERQAREHSERKKRRRESECKAA)
Additional Detail Fields 3 fields
HIV-1 Viral Protein R (Vpr), Enhanced Green Fluorescent Protein (EGFP), Cell-penetrating peptide (C peptide: GPGLWERQAREHSERKKRRRESECKAA)
CGGGTGGGTSSTTGGGTCC
MDA-MB-231 breast cancer cells, MCF-7 cells, NHFB normal breast cells, A549 lung cancer cells, HeLa cervical cancer cells, HepG2 hepatoma cells