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Peptide record

TPDB64101

RHDF-1 (Peptide1) Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB64101
RHDF-1 (Peptide1)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
SLQRKKPPWLKLDIPSC-NH2
Physicochemical Analysis
C92H153N25O23S1
ANEGHMFTYV
LKP
2009.44
10.32
4
1
5
+3
3.12
-0.712
91.76
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5500
273.71
4
Residue Composition
number
0
A
1
R
0
N
1
D
1
C
0
E
1
Q
0
G
0
H
1
I
3
L
3
K
0
M
0
F
3
P
2
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 1 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 3 K: 3 M: 0 F: 0 P: 3 S: 2 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
17
C92H153N25O23S1
2009.44
10.32
+3
3.12
-0.712
Amidation
L
Linear
Free
N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hl-60 And Hek293 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
The uptake of the original peptide (1) and its shorter derivatives (4 and 5) was poor
In vitro
CCCCCCCSSSSCCCTTC
Additional Detail Fields 1 fields
CCCCCCCSSSSCCCTTC