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Peptide record

TPDB64100

LYSPenetratin Cell-penetrating Peptides standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB64100
LYSPenetratin
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 26-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Lysosomal targeting sequence
Sequence
SLLKGRQGIYRQIKIWFQNRRMKWKK
Physicochemical Analysis
C155H253N49O33S1
ADCEHPTV
K
3363.08
12.43
9
0
10
+9
2.45
-1.169
75.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
12490
371.39
6
Residue Composition
number
0
A
4
R
1
N
0
D
0
C
0
E
3
Q
2
G
0
H
3
I
2
L
5
K
1
M
1
F
0
P
1
S
0
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 3 G: 2 H: 0 I: 3 L: 2 K: 5 M: 1 F: 1 P: 0 S: 1 T: 0 W: 2 Y: 1 V: 0
Chemical Descriptors
26
C155H253N49O33S1
3363.08
12.43
+9
2.45
-1.169
Free
Lysosomal targeting sequence
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

B3 And ARPE19 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
FITC-labelled
Lysosomes
For the Nicastrin and Penetratin series, the inclusion of a lysosomal targeting tag increased overall green fluorescence but a general decrease of red fluorescence from Lysotracker in ARPE19 cells, but not B3 cells.
In vitro
CCCSCCCC
Additional Detail Fields 1 fields
CCCSCCCC