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Peptide record

TPDB64099

LYSNicastrin Cell-penetrating Peptides modified_plain modified
30 amino acids
Basic Information
3D PDB MODEL
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Sequence-matched coordinates; source-recorded chemical modifications are not verified in this model.

TPDB64099
LYSNicastrin
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 30-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Lysosomal targeting sequence
Sequence
SLLKGRQGIYRLPRCVRSTARLARALSPAF
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
30 main sequence record
Free Activity
Lysosomal targeting sequence Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

B3 And ARPE19 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
FITC-labelled
Lysosomes
For the Nicastrin and Penetratin series, the inclusion of a lysosomal targeting tag increased overall green fluorescence but a general decrease of red fluorescence from Lysotracker in ARPE19 cells, but not B3 cells.
In vitro
CCCCSCCCC
Additional Detail Fields 1 fields
CCCCSCCCC