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Peptide record

TPDB64099

LYSNicastrin Cell-penetrating Peptides standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB64099
LYSNicastrin
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 30-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Lysosomal targeting sequence
Sequence
SLLKGRQGIYRLPRCVRSTARLARALSPAF
Physicochemical Analysis
C148H254N50O37S1
NDEHMW
R
3358.02
12.41
7
0
13
+7
1.85
-0.087
101.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1490
44.37
7
Residue Composition
number
4
A
6
R
0
N
0
D
1
C
0
E
1
Q
2
G
0
H
1
I
5
L
1
K
0
M
1
F
2
P
3
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 4 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 2 H: 0 I: 1 L: 5 K: 1 M: 0 F: 1 P: 2 S: 3 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
30
C148H254N50O37S1
3358.02
12.41
+7
1.85
-0.087
Free
Lysosomal targeting sequence
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

B3 And ARPE19 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
FITC-labelled
Lysosomes
For the Nicastrin and Penetratin series, the inclusion of a lysosomal targeting tag increased overall green fluorescence but a general decrease of red fluorescence from Lysotracker in ARPE19 cells, but not B3 cells.
In vitro
CCCCSCCCC
Additional Detail Fields 1 fields
CCCCSCCCC