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Peptide record

TPDB64092

PTD-3 Cell-penetrating Peptides modified_plain modified
23 amino acids
Basic Information
3D PDB MODEL
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Sequence-matched coordinates; source-recorded chemical modifications are not verified in this model.

TPDB64092
PTD-3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 23-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: iRGD peptide
Sequence
SKKKKKKKKKETWWETWWTEWGC-NH2
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
23 main sequence record
Amidation Activity
iRGD peptide Activity
L Activity
Amphipathic Activity
Linear Activity
Free Activity
N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

SUIT-2, MDA-MB-231, bEnd3 mouse endothelial, 4T1 mouse breast cancer cell

Assay & Model

Male BALB/c nude mice bearing tumor
Male BALB/c nude mice bearing tumor

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
AlexaFluor 546 (AF546) fluorescent dye
Transcytosis
In vitro and in vivo
CCCTTSCCCC
Additional Detail Fields 1 fields
CCCTTSCCCC