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Peptide record

TPDB64092

PTD-3 Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB64092
PTD-3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 23-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: iRGD peptide
Sequence
SKKKKKKKKKETWWETWWTEWGC-NH2
Physicochemical Analysis
C144H215N37O34S1
ARNDQHILMFPYV
K
3040.58
10.43
9
3
5
+6
6.04
-2.213
0.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
27500
904.43
5
Residue Composition
number
0
A
0
R
0
N
0
D
1
C
3
E
0
Q
1
G
0
H
0
I
0
L
9
K
0
M
0
F
0
P
1
S
3
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 1 E: 3 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 9 M: 0 F: 0 P: 0 S: 1 T: 3 W: 5 Y: 0 V: 0
Chemical Descriptors
23
C144H215N37O34S1
3040.58
10.43
+6
6.04
-2.213
Amidation
iRGD peptide
L
Amphipathic
Linear
Free
N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

SUIT-2, MDA-MB-231, bEnd3 mouse endothelial, 4T1 mouse breast cancer cell

Assay & Model

Male BALB/c nude mice bearing tumor
Male BALB/c nude mice bearing tumor

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
AlexaFluor 546 (AF546) fluorescent dye
Transcytosis
In vitro and in vivo
CCCTTSCCCC
Additional Detail Fields 1 fields
CCCTTSCCCC