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Peptide record

TPDB64091

Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB64091
Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia CPPsite3.0 TumorHoPe2.0
standard
No
A 4-aa standard natural multi-activity (Blood-Brain Barrier, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from Peptipedia, CPPsite3.0, and TumorHoPe2.0, with an available 3D structural model.
C-terminal: Biotin N-terminal: Fluorescein isothiocyanate (FITC)
Sequence
SIWV
Physicochemical Analysis
C25H37N5O6
ARNDCEQGHLKMFPTY
ISWV
503.60
6.02
0
0
3
-0
-1.96
1.750
170.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5500
1092.14
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
4
C25H37N5O6
503.60
6.02
-0
-1.96
1.750
Biotin
Fluorescein isothiocyanate (FITC)
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Homing, Penetrating
Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
A brain tumor-homing tetra-peptide delivers a nano-therapeutic for more effective treatment of a mouse model of glioblastoma
2020
Kang R H et al. Nanoscale Horiz.2020 Jul 27 5(8):1213-1225
Patent pending

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Human-derived brain carcinoma cells (U87MG cells), lung carcinoma cells (A549 cells), liver carcinoma cells (Huh7 cells)
5- or 6-week-old female BALB/c nu/nu mice, 7-week-old ICR mice
A33H
Fluorescein isothiocyanate (FITC)
Cell penetrating peptide
Additional Detail Fields 3 fields
Fluorescein isothiocyanate (FITC)
Human-derived brain carcinoma cells (U87MG cells), lung carcinoma cells (A549 cells), liver carcinoma cells (Huh7 cells)
5- or 6-week-old female BALB/c nu/nu mice, 7-week-old ICR mice