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Peptide record

TPDB64090

SIAED Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64090
SIAED
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
SIAEDQTISTPK
Physicochemical Analysis
C54H92N14O22
RNCGHLMFWYV
IST
1289.41
4.07
1
2
3
-1
5.02
-0.683
73.33
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
1
E
1
Q
0
G
0
H
2
I
0
L
1
K
0
M
0
F
1
P
2
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 2 L: 0 K: 1 M: 0 F: 0 P: 1 S: 2 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C54H92N14O22
1289.41
4.07
-1
5.02
-0.683
Free
L
Linear
Free
N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mc3T3-E1 Cell Line, Caco-2 Cells,

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
eGFP at C terminus
High uptake compared to the unmodified negative control eGFP in MC3TS-E1 cells but no uptake in Caco-2 cells
In vitro
CCCCCCCSSSCC
Additional Detail Fields 1 fields
CCCCCCCSSSCC