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Peptide record

TPDB64081

SR11 Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB64081
SR11
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
SGASDDEEIAR
Physicochemical Analysis
C44H72N14O22
NCQHLKMFPTWYV
ADES
1149.14
3.59
1
4
3
-3
6.93
-1.127
53.64
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
1
R
0
N
2
D
0
C
2
E
0
Q
1
G
0
H
1
I
0
L
0
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 2 C: 0 E: 2 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C44H72N14O22
1149.14
3.59
-3
6.93
-1.127
Free
L
Anionic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa And Hacat Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Anionic
Protein derived
FITC dye and Imatinib Mesylate
Cytoplasm (More) And Nucleus (Less)
Time and concentration-dependent internalization but less than IR15
Lipid-raft mediated endocytosis
In vitro
CCCCTTCTTCSCCCCCSCC
Additional Detail Fields 1 fields
CCCCTTCTTCSCCCCCSCC