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Peptide record

TPDB64079

Peptide 27 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64079
Peptide 27
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 12-aa standard-residue cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
Sequence
SFHQFARATLAS
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C60H90N18O17
NDCEGIKMPWYV
A
1335.49
11.05
2
0
6
+1
1.52
0.108
57.50
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
3
A
1
R
0
N
0
D
0
C
0
E
1
Q
0
G
1
H
0
I
1
L
0
K
0
M
2
F
0
P
2
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 2 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
12 main sequence record
C60H90N18O17 sequence-only estimate (linear, free termini)
1335.49 sequence-only estimate (linear, free termini)
11.05 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
1.52 sequence-only estimate (linear, free termini)
0.108 sequence-only estimate (linear, free termini)
L Activity
Linear Activity
N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HIG-82 cells

Source & Reference

CPPsite3.0
CPPsite3
US 6881825

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Phages
In vitro
CCSHHHHHTTC
Additional Detail Fields 1 fields
CCSHHHHHTTC