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Peptide record

TPDB64077

H2 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB64077
H2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
SERKKRRRESECKAA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C72H132N30O24S1
NDQGHILMFPTWYV
R
1834.09
10.79
7
3
2
+4
6.58
-2.380
13.33
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
2
A
4
R
0
N
0
D
1
C
3
E
0
Q
0
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 0 C: 1 E: 3 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15 main sequence record
C72H132N30O24S1 sequence-only estimate (linear, free termini)
1834.09 sequence-only estimate (linear, free termini)
10.79 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
6.58 sequence-only estimate (linear, free termini)
-2.380 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
EGFP protein
Cytoplasm and nucleus
EGFP-H3 and EGFP-H4 showed higher cellular uptake than that of EGFP-HBD, EGFP-H1 and EGFP-H3
In vitro
CTTSCCCCSCSSCCC
Additional Detail Fields 1 fields
CTTSCCCCSCSSCCC