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Peptide record

TPDB64064

PTH(1-34)-penetratin Cell-penetrating Peptides modified_plain modified
52 amino acids
Basic Information
TPDB64064
PTH(1-34)-penetratin
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 52-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, without an available 3D structural model.
N-terminal: Addition of Serine
Sequence
S*SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNFRQIKIWFQNRRMKWKK
Physicochemical Analysis
C288H462N90O72S3
ACPTY
K
6433.58
11.54
15
4
19
+8
13.66
-0.987
76.73
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
16500
256.47
12
Residue Composition
number
0
A
5
R
4
N
1
D
0
C
3
E
4
Q
1
G
3
H
3
I
5
L
7
K
3
M
2
F
0
P
4
S
0
T
3
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 5 N: 4 D: 1 C: 0 E: 3 Q: 4 G: 1 H: 3 I: 3 L: 5 K: 7 M: 3 F: 2 P: 0 S: 4 T: 0 W: 3 Y: 0 V: 3
Chemical Descriptors
52
C288H462N90O72S3
6433.58
11.54
+8
13.66
-0.987
Free
L
Linear
Addition of Serine
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 Cell Monolayer And Saos-2

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Chimeric
PTH(1-34) peptide
N-terminal conjugation increased the permeation of the fusion peptide significantly as compared to C-terminal conjugation
In vitro