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Peptide record

TPDB64046

Pip6a Cell-penetrating Peptides modified_plain modified
22 amino acids
Basic Information
3D PDB MODEL
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TPDB64046
Pip6a
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 22-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: B, Beta-Alanine and X, 6-aminohexanoic acid (Ahx) N-terminal: Acetylation
Sequence
Ac-RXRRBRRXRYQFLIRXRBRXRB
Physicochemical Analysis
C95H170N46O18
ANDCEGHKMPSTWV
R
2244.69
13.00
10
0
4
+10
5.74
-1.759
35.45
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
66.38
2
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
22
C95H170N46O18
2244.69
13.00
+10
5.74
-1.759
Free
B, Beta-Alanine and X, 6-aminohexanoic acid (Ahx)
Modified
Linear
Acetylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Murine H2k mdx myoblasts and C2C12 cells

Assay & Model

1- to 2-day-old newborn wild-type C57BL/6 J mice
1- to 2-day-old newborn wild-type C57BL/6 J mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified
Synthetic
Nucleic acid [phosphorodiamidate morpholino oligomers (PMO)]
Vesicles
Dose dependent uptake
Energy and caveolae-mediated endocytosis
In vitro and in vivo