TPDB

3D PDB MODEL

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Sequence-matched coordinates; source-recorded chemical modifications are not verified in this model.

TPDB ID TPDB64044

Peptide_Name

Bpep

Activity

Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

CPPsite3.0

Sequence_Type

modified_plain

Has_Modification Yes

Description A 12-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.

Modification

Chemical: B = β-alanine , X = aminohexanoic acid

Sequence

RXRRBRRXRRBR

Source notation is retained verbatim; residue identity and the source-provided length have not been independently validated.

FASTA

>TPDB64044|Cell-penetrating Peptides|length=12
RXRRBRRXRRBR

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Length

12 main sequence record

C_terminal_Modification

Free Activity

Chemical_Modification

B = β-alanine , X = aminohexanoic acid Activity

Chirality

Modified Activity

Linearity

Linear Activity

N_terminal_Modification

Free Activity

SMILES

NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)O Activity

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Dc2.4 Dcs , Splenocytes From C57Bl/6 Mice

Assay & Model

In Vitro Model C57BL/6 mice

In Vivo Model C57BL/6 mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear Modified

Cargo Type FITC-dye and gp100 peptide to the N terminus

Subcellular Localization Cytosol

Uptake Efficiency 18-fold increase with Bpep in dendritic cells

Uptake Mechanism Endocytosis

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCSTTTSCSGGGCSSSSCCCSSTTCCC

DSSP_Secondary_Structure

CCSTTTSCSGGGCSSSSCCCSSTTCCC