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Peptide record

TPDB64034

DL-3 Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB64034
DL-3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RWSSKKSKHCG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C55H90N20O15S1
ANDEQILMFPTYV
KS
1303.50
10.83
5
0
1
+4
3.81
-1.873
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
4.22
4
Residue Composition
number
0
A
1
R
0
N
0
D
1
C
0
E
0
Q
1
G
1
H
0
I
0
L
3
K
0
M
0
F
0
P
3
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 3 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
11 main sequence record
C55H90N20O15S1 sequence-only estimate (linear, free termini)
1303.50 sequence-only estimate (linear, free termini)
10.83 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
3.81 sequence-only estimate (linear, free termini)
-1.873 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cationic Activity
Linear Activity
Free Activity
N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CS)C(=O)NCC(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Abdominal Skin From Male Kunming (Km) Mice

Assay & Model

Male Kunming (KM) mice
Male Kunming (KM) mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Triptolide (TP)
Accumulative penetration amount of TP is decreased
In vitro and in vivo
CCSCCSSSCC
Additional Detail Fields 1 fields
CCSCCSSSCC