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Peptide record

TPDB64023

RW9 Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB64023
RW9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
Sequence
RWRRWWRRW
Physicochemical Analysis
C74H102N28O10
ANDCEQGHILKMFPSTYV
R
1543.81
13.00
5
0
4
+5
-3.35
-2.900
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
1425.05
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
9
C74H102N28O10
1543.81
13.00
+5
-3.35
-2.900
Free
L
Amphipathic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Standard and Annexin 2-GFP transfected MDCK cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Nanoparticle (PMS labelled with the fluorescent probe di-4-ANEPPDHQ)
More efficient peptide in provoking protrusions
Endocytosis, direct translocation or physical endocytosis
In vitro
CCSCCCCCC
Additional Detail Fields 1 fields
CCSCCCCCC