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Peptide record

TPDB64016

2-W Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB64016
2-W
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with FAM via Lysine residue
Sequence
RWIKIWFQNRRMKWKK
Physicochemical Analysis
C110H170N34O19S1
ADCEGHLPSTYV
K
2304.84
12.72
7
0
7
+7
-0.14
-1.569
48.75
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
715.89
2
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
1
Q
0
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
16
C110H170N34O19S1
2304.84
12.72
+7
-0.14
-1.569
Conjugated with FAM via Lysine residue
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hcec And Nhc Cells

Assay & Model

Male mice (18 − 20 g)
Male mice (18 − 20 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FAM dye
Cells treated by 2-W and 28-W exhibited relatively higher uptake, 2.8 fold in NHC cells for 2-W.
In-vitro, in-vivo and ex vivo
CHHHHTEETTEETTBC
Additional Detail Fields 1 fields
CHHHHTEETTEETTBC