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Peptide record

TPDB64009

No. 2175 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB64009
No. 2175
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Conjugation with fluorescein
Sequence
RVREWWYTITLKQES
Physicochemical Analysis
C92H139N25O25
ANDCGHMFP
RETW
1995.27
9.74
3
2
6
+1
2.20
-1.080
71.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12490
625.98
5
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
2
E
1
Q
0
G
0
H
1
I
1
L
1
K
0
M
0
F
0
P
1
S
2
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 2 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 0 S: 1 T: 2 W: 2 Y: 1 V: 1
Chemical Descriptors
15
C92H139N25O25
1995.27
9.74
+1
2.20
-1.080
Free
L
Amphipathic
Linear
Conjugation with fluorescein
N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Jurkat and CHO

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Fluorophore (fluorescein)
Similar or greater than TAT in CHO cells, Greater
In vitro
CCCCSSCSSCCCCCC
Additional Detail Fields 1 fields
CCCCSSCSSCCCCCC