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Peptide record

TPDB64006

(SEQ ID NO: 29) Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB64006
(SEQ ID NO: 29)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 16-aa standard-residue cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
Sequence
RVIRVWFQNKRCKDKK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C94H158N32O21S1
AEGHLMPSTY
K
2104.55
11.53
7
1
5
+6
4.27
-1.394
60.62
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
2.61
3
Residue Composition
number
0
A
3
R
1
N
1
D
1
C
0
E
1
Q
0
G
0
H
1
I
0
L
4
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 1 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
16 main sequence record
C94H158N32O21S1 sequence-only estimate (linear, free termini)
2104.55 sequence-only estimate (linear, free termini)
11.53 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
4.27 sequence-only estimate (linear, free termini)
-1.394 sequence-only estimate (linear, free termini)
L Activity
Linear Activity
N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

9 L/LacZ cells

Source & Reference

CPPsite3.0
CPPsite3
US 20060035815

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Nucleic acid (siRNA)
In vitro
CCCCCCCCCCCCSSCC
Additional Detail Fields 1 fields
CCCCCCCCCCCCSSCC