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Peptide record

TPDB64002

hAP10 DR (RT33 DR) Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB64002
hAP10 DR (RT33 DR)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
RSRSRRRRRK
Physicochemical Analysis
C54H108N32O13
ANDCEQGHILMFPTWYV
R
1413.66
13.18
8
0
0
+8
6.92
-3.700
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C54H108N32O13
1413.66
13.18
+8
6.92
-3.700
Free
L
Cationic
Linear
Conjugated with FITC
N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CS)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U2Os And C8161 Cancer Cells

Assay & Model

HUT78 Sézary bearing NOD/SCID gamma (NSG) mice
HUT78 Sézary bearing NOD/SCID gamma (NSG) mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
FITC dye , EGFP and survival protein AAC-11
Internalized approximately twice as more efficiently than hAP10 and about 50% more than TAT
Macropinocytosis
In vitro and in vivo
CCCCTTSSCC
Additional Detail Fields 1 fields
CCCCTTSSCC