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Peptide record

TPDB63999

protamine Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB63999
protamine
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Methylene Blue Attached
Sequence
RSQSRSRYYRQRQRSRRRRRRS
Physicochemical Analysis
C120H213N61O33
ANDCEGHILKMFPTWV
R
3038.40
12.88
12
0
2
+12
10.23
-3.232
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
2980
98.08
10
Residue Composition
number
0
A
12
R
0
N
0
D
0
C
0
E
3
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
5
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 12 N: 0 D: 0 C: 0 E: 0 Q: 3 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 5 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
22
C120H213N61O33
3038.40
12.88
+12
10.23
-3.232
Free
L
Linear
Methylene Blue Attached
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Ht-29 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Methylene blue (MB)
Lysosomes
More penetration than MB alone
Endocytosis
In vitro
CCTTHHHHTTTTTTC
Additional Detail Fields 1 fields
CCTTHHHHTTTTTTC