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Peptide record

TPDB63991

CPP1 Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB63991
CPP1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RRYRRRRRYFRKRR
Physicochemical Analysis
C93H161N45O17
ANDCEQGHILMPSTWV
R
2181.59
12.77
11
0
3
+11
6.08
-3.479
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
2980
136.60
2
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
1
F
0
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
14
C93H161N45O17
2181.59
12.77
+11
6.08
-3.479
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Df-1, Vero And RAW264.7 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
FITC dye, SYTO 64 fluorescent dye, plasmids ,SUMO-Rep or SUMO-Cap protein and CAV VP3 gene
Cytoplasm and Nuclear Areas
74.5±1.56 internalization percentages of the cells treated with 5 μM CPP1
Clathrin- and Caveolae-dependent endocytosis and macropinocytosis
In vitro
CCGGGTSCC
Additional Detail Fields 1 fields
CCGGGTSCC