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Peptide record

TPDB63989

R2W4R2 Cell-penetrating Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB63989
R2W4R2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 8-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RRWWWWRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C68H90N24O9
ANDCEQGHILKMFPSTYV
RW
1387.62
12.88
4
0
4
+4
6.30
-2.700
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
15.85
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
8 main sequence record
C68H90N24O9 sequence-only estimate (linear, free termini)
1387.62 sequence-only estimate (linear, free termini)
12.88 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
6.30 sequence-only estimate (linear, free termini)
-2.700 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Amphipathic Activity
Linear Activity
Free Activity
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)O Activity
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
FITC labelled
In vitro
CCTTSSCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Synthetic
FITC dye and Methotrexate (MTX)
Most cellular uptake than all
In vitro
CCSCCHHHHHHHHHHCC
Additional Detail Fields 1 fields
CCTTSSCCCCC CCSCCHHHHHHHHHHCC