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Peptide record

TPDB63984

inverse-R6W3 Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB63984
inverse-R6W3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
RRWRRWWRR-NH2
Physicochemical Analysis
C69H104N30O10
ANDCEQGHILKMFPSTYV
R
1513.78
13.10
6
0
3
+6
-0.69
-3.300
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
1089.99
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
9
C69H104N30O10
1513.78
13.10
+6
-0.69
-3.300
Amidation
L
Amphiphilic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Synthetic
Dex10-AF594 dye
The cellular uptake of Dex10-AF594 in the presence of inverse-R6W3 was comparable to that of R6W3 (i.e., four-fold that of untreated cells).
Endocytosis
In vitro
CCTHHHHCC
Additional Detail Fields 1 fields
CCTHHHHCC