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Peptide record

TPDB63983

C2-P4 Cell-penetrating Peptides standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB63983
C2-P4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 32-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: IMT-P8 (C2) at N terminus
Sequence
RRWRRWNRFNRRRCRRRLQQTQAQVDEVVDIM
Physicochemical Analysis
C180H299N73O46S2
GHKPSY
R
4285.94
12.48
11
3
10
+8
10.56
-1.675
54.69
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
256.65
8
Residue Composition
number
1
A
11
R
2
N
2
D
1
C
1
E
4
Q
0
G
0
H
1
I
1
L
0
K
1
M
1
F
0
P
0
S
1
T
2
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 11 N: 2 D: 2 C: 1 E: 1 Q: 4 G: 0 H: 0 I: 1 L: 1 K: 0 M: 1 F: 1 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 3
Chemical Descriptors
32
C180H299N73O46S2
4285.94
12.48
+8
10.56
-1.675
Free
IMT-P8 (C2) at N terminus
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

PC-12 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
SNARE motif of VAMP2-patterned peptide (CVPs)
In vitro
CCCCSSCCSSTTTTSSSSGGGSCSCCCCCCC
Additional Detail Fields 1 fields
CCCCSSCCSSTTTTSSSSGGGSCSCCCCCCC