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Peptide record

TPDB63981

C2-P3 Cell-penetrating Peptides standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB63981
C2-P3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 32-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: IMT-P8 (C2) at N terminus
Sequence
RRWRRWNRFNRRRCRLSEIETRHSEIIKLENS
Physicochemical Analysis
C181H298N70O48S1
ADQGMPYV
R
4254.86
12.23
12
4
8
+7
12.80
-1.722
60.94
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
258.53
8
Residue Composition
number
0
A
10
R
3
N
0
D
1
C
4
E
0
Q
0
G
1
H
3
I
2
L
1
K
0
M
1
F
0
P
3
S
1
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 3 D: 0 C: 1 E: 4 Q: 0 G: 0 H: 1 I: 3 L: 2 K: 1 M: 0 F: 1 P: 0 S: 3 T: 1 W: 2 Y: 0 V: 0
Chemical Descriptors
32
C181H298N70O48S1
4254.86
12.23
+7
12.80
-1.722
Free
IMT-P8 (C2) at N terminus
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

PC-12 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
SNARE motif of VAMP2-patterned peptide (CVPs)
In vitro
CCCCSCTTTCTTCCCCCCTTSHHHHHHHHHHC
Additional Detail Fields 1 fields
CCCCSCTTTCTTCCCCCCTTSHHHHHHHHHHC