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Peptide record

TPDB63977

C2-P5 Cell-penetrating Peptides standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB63977
C2-P5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 29-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: IMT-P8 (C2) at N terminus
Sequence
RRWRRWNRFNRRRCRDARENEMDENLEQV
Physicochemical Analysis
C162H260N66O47S2
GHIKPSTY
R
3948.38
11.80
10
6
7
+4
14.94
-2.355
26.90
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
278.60
6
Residue Composition
number
1
A
10
R
4
N
2
D
1
C
4
E
1
Q
0
G
0
H
0
I
1
L
0
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 10 N: 4 D: 2 C: 1 E: 4 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
29
C162H260N66O47S2
3948.38
11.80
+4
14.94
-2.355
Free
IMT-P8 (C2) at N terminus
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)O.C
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

PC-12 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
SNARE motif of VAMP2-patterned peptide (CVPs)
In vitro
CCCCTTCSSCSGGGTTTTHHHHCSGGGCCCCC
Additional Detail Fields 1 fields
CCCCTTCSSCSGGGTTTTHHHHCSGGGCCCCC