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Peptide record

TPDB63975

LP-P1 Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB63975
LP-P1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RRWRIVVIRVRRC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C77H138N32O14S1
ANDEQGHLKMFPSTY
R
1768.21
12.70
6
0
6
+6
4.92
-0.292
126.92
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
3.11
1
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
2
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
13 main sequence record
C77H138N32O14S1 sequence-only estimate (linear, free termini)
1768.21 sequence-only estimate (linear, free termini)
12.70 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
4.92 sequence-only estimate (linear, free termini)
-0.292 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cationic Activity
Linear Activity
Free Activity
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

P. aeruginosa and MRSA

Assay & Model

BALb/c mice (8 weeks, 18–20 g, male)
BALb/c mice (8 weeks, 18–20 g, male)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Liposomes (LP)
Membrane damage
In vitro and in vivo
CCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCC